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Clomiphene is a resistance hormone drug

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  Clomiphene is a resistance hormone drug. The mechanism by which Clomiphene stimulates ovulation is not fully understood. Because Clomiphene has a weak effect on estrogen and strong antagonism, stimulating ovulation may be in the hypothalamic region, first antagonizing predominance, by competitively occupying the hypothalamic estrogen receptor, interfering with the negative feedback of endogenous estrogen Promote the secretion of luteinizing hormone and follicle-stimulating hormone, and then stimulate the growth of follicles. After the follicles mature, the release of estrogen increases, and the positive gonadotropin release peaks after positive feedback, so ovulation, treatment of males Infertility may be associated with elevated FSH and LH and promotion of spermatogenesis.

  After oral administration of Clomiphene, it is absorbed through the intestine and enters the hepatic blood circulation. T1/2 is generally 5 to 7 days. This product is metabolized in the liver. Enter the intestine with bile, then excrete from the feces, and some re-absorbed through the liver and intestine. Half out of the feces within 5 days. It can still be measured in feces within 6 weeks.