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Miglitol is a second-generation glycosidase inhibitor

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  Miglitol is a second-generation glycosidase inhibitor. Miglitol is a small molecule compound with a structure similar to glucose. During the digestion of food, alpha-glucosidase (including maltase, isomaltase, invertase, glucoamylase, etc.) can hydrolyze polysaccharides and oligosaccharides in foods into monosaccharides (including glucose). Alpha-glycosidase inhibitors can delay the production and absorption of glucose, thereby alleviating the dramatic changes in postprandial hyperglycemia and subsequent blood glucose in diabetic patients. Miglitol mainly acts on the small intestine and has little effect on the hydrolysis of carbohydrates in the colon. The adverse reactions of gastrointestinal tract secondary to the fermentation of unabsorbed sugars are less common than acarbose.

  Miglitol is more easily absorbed in the small intestine than acarbose, and the degree of absorption by oral administration decreases with increasing dose. The bioavailability of oral 25 mg drug is 100%, the bioavailability of oral 100 mg drug is about 50% to 70%, and the absorption can reach saturation at higher doses. Its protein binding rate is less than 4%, and the volume of distribution is 0.18 L/kg. Less metabolism in the body, more than 95% excreted from the urine in the original form, when the dose exceeds 25mg, due to incomplete absorption, a small amount of drug can be reabsorbed by urine. Miglitol has a half-life of 2 h.