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Pharmacological action of amorolfine

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Amorolfine is a topical antifungal drug whose mechanism of action is to inhibit the various steps of fungal cell wall ergosterol biosynthesis, which interferes with the synthesis of fungal cell membrane ergosterol and leads to fungal death. Amorolfine has antibacterial activity against various pathogenic bacteria such as dermatophytes, candida, dermatitis buds, cryptococcus, capsular histoplasma, and S. sphaeroides. Amorolfine is effective against vaginal Candida albicans, hyperthyroidism and various dermatophytosis, and is ineffective against vaginal Gram-positive bacterial infections and has no effect on organ fungal infections.


Amorolfine cream forms a water-insoluble film on the deck and penetrates the deck within 24 hours to a concentration well above the minimum inhibitory concentration (MIC) for one week. After topical application, 4% to 10% is absorbed into the blood, and the blood concentration is less than 0.5 ng/ml. The duration of action on the skin is maintained for at least 24 hours. The absorbed drug is mainly discharged from the urine, and a small amount is discharged from the feces.